TY - JOUR
T1 - Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea
AU - Kimitsuki, Takashi
AU - Ohashi, Mitsuru
AU - Umeno, Yoshihiro
AU - Yoshida, Takamasa
AU - Komune, Noritaka
AU - Noda, Teppei
AU - Komune, Shizuo
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research 21592160 from the Ministry of Education, Culture, Sports, Science and Technology of Japan .
PY - 2011/10/17
Y1 - 2011/10/17
N2 - Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly reduced the outward K currents (I K,f), but did not affect the inward current (I K,n). Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66mM, and the Hill coefficient of 1.86.
AB - Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly reduced the outward K currents (I K,f), but did not affect the inward current (I K,n). Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66mM, and the Hill coefficient of 1.86.
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U2 - 10.1016/j.neulet.2011.08.050
DO - 10.1016/j.neulet.2011.08.050
M3 - Article
C2 - 21896315
AN - SCOPUS:80053440903
SN - 0304-3940
VL - 504
SP - 28
EP - 31
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -