TY - JOUR
T1 - Effect of post-gastrectomy adjuvant S-1 chemotherapy on muscle volume in gastric cancer patients
AU - Iwazawa, Takashi
AU - Kawanishi, Kenshu
AU - Fujita, Junya
AU - Takata, Akihiro
AU - Hirota, Masashi
AU - Imamura, Hiroshi
AU - Ikeda, Atsuyo
AU - Hokonohara, Kentarou
AU - Yoneyama, Chizu
AU - Kameyama, Akira
AU - Shinke, Go
AU - Oshima, Kazuteru
AU - Tanida, Tsukasa
AU - Hatano, Hisanori
AU - Noda, Takehiro
AU - Komori, Takamichi
AU - Morita, Shunji
AU - Akagi, Kenzou
AU - Dono, Keizou
PY - 2015/8
Y1 - 2015/8
N2 - Objective: To examine the effect of S-1 adjuvant chemotherapy on muscle volume after curative gastrectomy in gastric cancer patients. Patients: Forty-eight gastric cancer patients (31 men and 17 women) who underwent curative gastrectomy (distal gastrectomy: n=37, and total gastrectomy: n=11) between April 2010 and July 2011 were enrolled in this study. Sixteen patients underwent S-1 adjuvant chemotherapy (S-1 group) for 1 year after the operation, and 32 patients did not (NT group). Methods: The psoas muscle areas were measured at the fourth lumbar vertebrae on CT images obtained before the operation, and at 6, 12, and 24 months after the operation. Muscle areas was statistically examined by comparing the preoperative and postoperative ratios. Results: The muscle areas 12 months after the operation decreased to 0.86±0.11 in the S-1 group and to 0.96+0.08 in the NT group (p<0.05), and the significant difference disappeared at 24 months (0.93±0.10 vs. 0.93+0.11, NS). In the patients who underwent distal gastrectomy, the muscle areas decreased to 0.90+0.05 in the S-1 group and to 0.96+0.09 in the NT group at 12 months (p<0.05). Meanwhile, in those who underwent total gastrectomy, the muscle areas decreased to 0.80+0.15 and 0.93+0.03, respectively (NS). Conclusions: S-1 adjuvant chemotherapy affected muscle volume loss after gastrectomy in the gastric cancer patients, but the patients recovered from the adverse effect by 12 months after chemotherapy.
AB - Objective: To examine the effect of S-1 adjuvant chemotherapy on muscle volume after curative gastrectomy in gastric cancer patients. Patients: Forty-eight gastric cancer patients (31 men and 17 women) who underwent curative gastrectomy (distal gastrectomy: n=37, and total gastrectomy: n=11) between April 2010 and July 2011 were enrolled in this study. Sixteen patients underwent S-1 adjuvant chemotherapy (S-1 group) for 1 year after the operation, and 32 patients did not (NT group). Methods: The psoas muscle areas were measured at the fourth lumbar vertebrae on CT images obtained before the operation, and at 6, 12, and 24 months after the operation. Muscle areas was statistically examined by comparing the preoperative and postoperative ratios. Results: The muscle areas 12 months after the operation decreased to 0.86±0.11 in the S-1 group and to 0.96+0.08 in the NT group (p<0.05), and the significant difference disappeared at 24 months (0.93±0.10 vs. 0.93+0.11, NS). In the patients who underwent distal gastrectomy, the muscle areas decreased to 0.90+0.05 in the S-1 group and to 0.96+0.09 in the NT group at 12 months (p<0.05). Meanwhile, in those who underwent total gastrectomy, the muscle areas decreased to 0.80+0.15 and 0.93+0.03, respectively (NS). Conclusions: S-1 adjuvant chemotherapy affected muscle volume loss after gastrectomy in the gastric cancer patients, but the patients recovered from the adverse effect by 12 months after chemotherapy.
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M3 - Article
C2 - 26321709
AN - SCOPUS:84978409968
SN - 0385-0684
VL - 42
SP - 957
EP - 960
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 8
ER -
