Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction

Tadashi Suga, Koichi Okita, Shingo Takada, Masashi Omokawa, Tomoyasu Kadoguchi, Takashi Yokota, Kagami Hirabayashi, Masashige Takahashi, Noriteru Morita, Masahiro Horiuchi, Shintaro Kinugawa, Hiroyuki Tsutsui

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111 Citations (Scopus)


Our previous study reported that intramuscular metabolic stress during low-intensity resistance exercise was significantly enhanced by combining blood flow restriction (BFR); however, they did not reach the levels achieved during high-intensity resistance exercise. That study was performed using a single set of exercise; however, usual resistance exercise consists of multiple sets with rest intervals. Therefore, we investigated the intramuscular metabolic stress during multiple-set BFR exercises, and compared the results with those during multiple-set highintensity resistance exercise. Twelve healthy young subjects performed 3 sets of 1-min unilateral plantar flexion (30 repetitions) with 1-min intervals under 4 different conditions: low intensity (L, 20 % 1 RM) and high intensity (H, 65 % 1 RM) without BFR, and L with intermittent BFR (IBFR, only during exercise) and with continuous BFR (CBFR, during rest intervals as well as exercise). Intramuscular metabolic stress, defined as intramuscular metabolites and pH, and muscle fiber recruitment were evaluated by 31P-magnetic resonance spectroscopy. The changes of intramuscular metabolites and pH during IBFR were significantly greater than those in L but significantly lower than those in H. By contrast, those changes in CBFR were similar to those in H. Moreover, the fast-twitch fiber recruitment, evaluating by a splitting Pi peak, showed a similar level to H. In conclusion, the multiple sets of lowintensity resistance exercise with continuous BFR could achieve with the same metabolic stress as multiple sets of high-intensity resistance exercise.

Original languageEnglish
Pages (from-to)3915-3920
Number of pages6
JournalEuropean Journal of Applied Physiology
Issue number11
Publication statusPublished - Nov 2012

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)


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