Effect of Dosing Time on Trazodone Kinetics

Shigeyuki Nakano; Nobuya Ogawa; Kouki Watanabe; Tetsuro Naruo; Nobuyuki Takaoka; Shigehiro Ohdo; Tatsuru Arai

doi:10.3999/jscpt.23.445

Effect of Dosing Time on Trazodone Kinetics

Shigeyuki Nakano, Nobuya Ogawa, Kouki Watanabe, Tetsuro Naruo, Nobuyuki Takaoka, Shigehiro Ohdo, Tatsuru Arai

Research output: Contribution to journal › Article › peer-review

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Abstract

Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher C_max and significantly larger AUC_o-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.

Original language	English
Pages (from-to)	445-451
Number of pages	7
Journal	Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Volume	23
Issue number	2
DOIs	https://doi.org/10.3999/jscpt.23.445
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)

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title = "Effect of Dosing Time on Trazodone Kinetics",

abstract = "Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUCo-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.",

author = "Shigeyuki Nakano and Nobuya Ogawa and Kouki Watanabe and Tetsuro Naruo and Nobuyuki Takaoka and Shigehiro Ohdo and Tatsuru Arai",

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T1 - Effect of Dosing Time on Trazodone Kinetics

AU - Nakano, Shigeyuki

AU - Ogawa, Nobuya

AU - Watanabe, Kouki

AU - Naruo, Tetsuro

AU - Takaoka, Nobuyuki

AU - Ohdo, Shigehiro

AU - Arai, Tatsuru

PY - 1992

Y1 - 1992

N2 - Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUCo-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.

AB - Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUCo-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.

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Effect of Dosing Time on Trazodone Kinetics

Abstract

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