TY - GEN
T1 - Effect of Co-Solvent on the solubility of ginger bioactive compounds in water using COSMO-RS calculations
AU - Jaapar, Syaripah Zaimah Syed
AU - Iwai, Yoshio
AU - Morad, Noor Azian
PY - 2014
Y1 - 2014
N2 - The effects of co-solvent to the solubility of ginger bioactive compounds, 6-gingerol, 6- shogaol, 8-gingerol and 10-gingerol in hot water were calculated using the conductor-like screening model for real solvent (COSMO-RS). In this work, ethanol was used as the co-solvent. The σ- profiles of the molecules were calculated using Gaussian software and the solubility were calculated using the COSMO-RS method. The solubility of these ginger bioactive compounds were calculated at 50 to 150°C.The amounts of ethanol used were 0 mol (binary system), 0.005, 0.010 and 0.015 mol. The results show that when the concentration (mole fraction of ethanol) of co-solvent increases, the solubility of ginger bioactive compounds increase. While the temperature increases, the concentration (mole fraction of ethanol) of co-solvent decreases.
AB - The effects of co-solvent to the solubility of ginger bioactive compounds, 6-gingerol, 6- shogaol, 8-gingerol and 10-gingerol in hot water were calculated using the conductor-like screening model for real solvent (COSMO-RS). In this work, ethanol was used as the co-solvent. The σ- profiles of the molecules were calculated using Gaussian software and the solubility were calculated using the COSMO-RS method. The solubility of these ginger bioactive compounds were calculated at 50 to 150°C.The amounts of ethanol used were 0 mol (binary system), 0.005, 0.010 and 0.015 mol. The results show that when the concentration (mole fraction of ethanol) of co-solvent increases, the solubility of ginger bioactive compounds increase. While the temperature increases, the concentration (mole fraction of ethanol) of co-solvent decreases.
UR - http://www.scopus.com/inward/record.url?scp=84906972006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906972006&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMM.624.174
DO - 10.4028/www.scientific.net/AMM.624.174
M3 - Conference contribution
AN - SCOPUS:84906972006
SN - 9783038352259
T3 - Applied Mechanics and Materials
SP - 174
EP - 178
BT - Advanced Development in Automation, Materials and Manufacturing
PB - Trans Tech Publications Ltd
T2 - 2014 International Conference on Mechatronics, Materials and Manufacturing, ICMMM 2014
Y2 - 2 August 2014 through 4 August 2014
ER -