TY - JOUR
T1 - Effect of chronic inhibition of angiotensin converting enzyme on baroreceptor reflex in essential hypertension
AU - Muratani, H.
AU - Kimura, Y.
AU - Matsumura, K.
AU - Noda, Y.
AU - Eto, T.
AU - Fukiyama, K.
N1 - Funding Information:
We thank Professor Iimura and Dr. Shimamoto of Sapporo Medical College for their kindness to offer the anti-Ang I 1 antibody. We also thank Miss Chiemi Tanahara for her technical assistance. This study was supported by a grant from the Ministry of Health and Welfare (62A-6).
PY - 1988
Y1 - 1988
N2 - We examined baroreflex function and plasma angiotensin II (Ang II) before and after the treatment with an angiotensin converting enzyme inhibitor (ACEI) in eight inpatients with essential hypertension (EHT). Baroreflex sensitivity (BS), expressed as a slope of linear relationship between %changes in mean blood pressure (BP) and those in plasma concentration of norepinephrine (pNE), was greater during BP reduction by sodium nitroprusside (SNP) than during BP elevation by phenylephrine (PE). Enalapril treatment for 7 days reduced BP without a significant change in heart rate and pNE. It also increased the BS in two cases during SNP infusion and in four cases during PE infusion. Ang II was not significantly reduced after enalapril, while plasma ACE activity was suppressed by about 80 % and plasma renin activity (PRA) was elevated. The changes in BS did not correlate with the changes in Ang II. The shift of barofunction curve with an enhancement of BS by enalapril therapy might not be attributed solely to the interaction between circulating Ang II and central baroreflex mechanisms.
AB - We examined baroreflex function and plasma angiotensin II (Ang II) before and after the treatment with an angiotensin converting enzyme inhibitor (ACEI) in eight inpatients with essential hypertension (EHT). Baroreflex sensitivity (BS), expressed as a slope of linear relationship between %changes in mean blood pressure (BP) and those in plasma concentration of norepinephrine (pNE), was greater during BP reduction by sodium nitroprusside (SNP) than during BP elevation by phenylephrine (PE). Enalapril treatment for 7 days reduced BP without a significant change in heart rate and pNE. It also increased the BS in two cases during SNP infusion and in four cases during PE infusion. Ang II was not significantly reduced after enalapril, while plasma ACE activity was suppressed by about 80 % and plasma renin activity (PRA) was elevated. The changes in BS did not correlate with the changes in Ang II. The shift of barofunction curve with an enhancement of BS by enalapril therapy might not be attributed solely to the interaction between circulating Ang II and central baroreflex mechanisms.
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U2 - 10.3109/10641968809075995
DO - 10.3109/10641968809075995
M3 - Article
C2 - 2854015
AN - SCOPUS:0024265156
SN - 1064-1963
VL - A10
SP - 391
EP - 398
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - S1
ER -