Effect of Cepharanthin to prevent radiation induced xerostomia in head and neck cancer

Hajime Imada; Satoshi Nomoto; Takayuki Ohguri; Katsuya Yahara; Fumio Kato; Tomoaki Morioka; Yukunori Korogi

Effect of Cepharanthin to prevent radiation induced xerostomia in head and neck cancer

Hajime Imada, Satoshi Nomoto, Takayuki Ohguri, Katsuya Yahara, Fumio Kato, Tomoaki Morioka, Yukunori Korogi

Research output: Contribution to journal › Article › peer-review

Abstract

We retrospectively examined the effect of Cepharanthin to prevent radiation xerostomia in 37 cases of head and neck cancer. In the Cepharanthin group, the degree of xerostomia was milder than in the non-Cepharanthin group in spite of higher normal tissue complication probability (NTCP) and mean dose (MD) of parotid glands. In the non-Cepharanthin group, the degree of xerostomia was significantly correlated with NTCP and MD of parotid glands. MD of parotid glands and use of Cepharanthin were significantly related to more severe xerostomia by multivariate analysis with logistic regression. Cepharanthin may prevent radiation xerostomia after radiotherapy for head and neck cancer.

Original language	English
Pages (from-to)	1041-1045
Number of pages	5
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	31
Issue number	7
Publication status	Published - Jul 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "We retrospectively examined the effect of Cepharanthin to prevent radiation xerostomia in 37 cases of head and neck cancer. In the Cepharanthin group, the degree of xerostomia was milder than in the non-Cepharanthin group in spite of higher normal tissue complication probability (NTCP) and mean dose (MD) of parotid glands. In the non-Cepharanthin group, the degree of xerostomia was significantly correlated with NTCP and MD of parotid glands. MD of parotid glands and use of Cepharanthin were significantly related to more severe xerostomia by multivariate analysis with logistic regression. Cepharanthin may prevent radiation xerostomia after radiotherapy for head and neck cancer.",

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T1 - Effect of Cepharanthin to prevent radiation induced xerostomia in head and neck cancer

AU - Imada, Hajime

AU - Nomoto, Satoshi

AU - Ohguri, Takayuki

AU - Yahara, Katsuya

AU - Kato, Fumio

AU - Morioka, Tomoaki

AU - Korogi, Yukunori

PY - 2004/7

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N2 - We retrospectively examined the effect of Cepharanthin to prevent radiation xerostomia in 37 cases of head and neck cancer. In the Cepharanthin group, the degree of xerostomia was milder than in the non-Cepharanthin group in spite of higher normal tissue complication probability (NTCP) and mean dose (MD) of parotid glands. In the non-Cepharanthin group, the degree of xerostomia was significantly correlated with NTCP and MD of parotid glands. MD of parotid glands and use of Cepharanthin were significantly related to more severe xerostomia by multivariate analysis with logistic regression. Cepharanthin may prevent radiation xerostomia after radiotherapy for head and neck cancer.

AB - We retrospectively examined the effect of Cepharanthin to prevent radiation xerostomia in 37 cases of head and neck cancer. In the Cepharanthin group, the degree of xerostomia was milder than in the non-Cepharanthin group in spite of higher normal tissue complication probability (NTCP) and mean dose (MD) of parotid glands. In the non-Cepharanthin group, the degree of xerostomia was significantly correlated with NTCP and MD of parotid glands. MD of parotid glands and use of Cepharanthin were significantly related to more severe xerostomia by multivariate analysis with logistic regression. Cepharanthin may prevent radiation xerostomia after radiotherapy for head and neck cancer.

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Effect of Cepharanthin to prevent radiation induced xerostomia in head and neck cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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