TY - JOUR
T1 - Effect of body composition on outcomes after hepatic resection for hepatocellular carcinoma
AU - Itoh, Shinji
AU - Shirabe, Ken
AU - Matsumoto, Yoshihiro
AU - Yoshiya, Shohei
AU - Muto, Jun
AU - Harimoto, Norifumi
AU - Yamashita, Yo Ichi
AU - Ikegami, Toru
AU - Yoshizumi, Tomoharu
AU - Nishie, Akihiro
AU - Maehara, Yoshihiko
PY - 2014/9
Y1 - 2014/9
N2 - Purpose. To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). Methods. We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at the level of the umbilicus, into high VFA (H-VFA) (n = 106) and low VFA (L-VFA) (n = 84) groups. We compared the surgical outcomes between the two groups. Results. L-VFA was significantly correlated with a lower body mass index, sarcopenia, lower serum albumin, and liver cirrhosis. There was no difference in the incidence of postoperative complications and mortality between the 2 groups. Patients in the L-VFA group had a significantly poorer prognosis than those in the H-VFA group in terms of both overall (P = 0.043) and recurrence-free (P = 0.001) survival. The results of multivariate analysis showed that sarcopenia rather than L-VFA was an independent and prognostic indicator after hepatic resection with HCC. Conclusions. Body composition is an important factor affecting cancer outcomes after hepatic resection for HCC in Japan.
AB - Purpose. To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). Methods. We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at the level of the umbilicus, into high VFA (H-VFA) (n = 106) and low VFA (L-VFA) (n = 84) groups. We compared the surgical outcomes between the two groups. Results. L-VFA was significantly correlated with a lower body mass index, sarcopenia, lower serum albumin, and liver cirrhosis. There was no difference in the incidence of postoperative complications and mortality between the 2 groups. Patients in the L-VFA group had a significantly poorer prognosis than those in the H-VFA group in terms of both overall (P = 0.043) and recurrence-free (P = 0.001) survival. The results of multivariate analysis showed that sarcopenia rather than L-VFA was an independent and prognostic indicator after hepatic resection with HCC. Conclusions. Body composition is an important factor affecting cancer outcomes after hepatic resection for HCC in Japan.
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U2 - 10.1245/s10434-014-3686-6
DO - 10.1245/s10434-014-3686-6
M3 - Article
C2 - 24719020
AN - SCOPUS:84906237520
SN - 1068-9265
VL - 21
SP - 3063
EP - 3068
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 9
ER -
