Effect of Alkynyl Group on Reactivity in Photoaffinity Labeling with 2-Thienyl-Substituted α-Ketoamide

Takahiro Moriyama, Daiki Mizukami, Makoto Yoritate, Kazuteru Usui, Daisuke Takahashi, Eisuke Ota, Mikiko Sodeoka, Tadashi Ueda, Satoru Karasawa, Go Hirai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Minimalist photo-reactive probes, which consist of a photo-reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine-based and aryl azide-based minimalist probes are available, no keto-based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2-thienyl-substituted α-ketoamide bearing an alkyne group on the thiophene ring. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.

Original languageEnglish
Article numbere202103925
JournalChemistry - A European Journal
Volume28
Issue number11
DOIs
Publication statusPublished - Feb 19 2022

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Catalysis
  • Organic Chemistry

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