Ecomposite physiologic index, percent forced vital capacity and percent diffusing capacity for carbon monoxide could be predictors of pirfenidone tolerability in patients with idiopathic pulmonary fibrosis

Satoshi Konishi, Machiko Arita, Isao Ito, Hiromasa Tachibana, Takuya Takaiwa, Yasushi Fukuda, Naoki Watanabe, Kazuya Tsubouchi, Gen Masuda, Maki Tanaka, Youhei Kourogi, Kei Kunimasa, Akihiro Nishiyama, Masahiro Iwasaku, Akihiro Ito, Fumiaki Tokioka, Hiroshige Yoshioka, Toru Hashimoto, Tadashi Ishida

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective The goals of this study were to assess the efficacy and tolerability of pirfenidone in patients with idiopathic pulmonary fibrosis (IPF) and to identify predictors of tolerability to pirfenidone. Methods We conducted a retrospective observational study. When the patient showed deterioration in the percent forced vital capacity (%FVC) or experienced acute exacerbations or severe adverse events, treatment of the patient with pirfenidone was discontinued. We classified the patients who did not display progression following six months of pirfenidone treatment as the tolerant group and the patients who did display progression as the intolerant group. We retrospectively analyzed differences between the two groups in terms of baseline characteristics. The efficacy of pirfenidone was evaluated by the changes in vital capacity (VC) and %FVC before and after the start of treatment in the tolerant group. Patients A total of 20 patients who had been diagnosed with IPF were treated with pirfenidone. Results In the tolerant group, the baseline %FVC (p=0.01) and the percentage diffusing capacity of the lungs for carbon monoxide (DLCO, p=0.02) were significantly higher, and the baseline composite physiologic index (CPI) was significantly lower (p=0.009) than in the intolerant group. In the tolerant group, pirfenidone significantly reduced the decline in VC and %FVC of the patients after treatment. In the intolerant group, five patients discontinued pirfenidone treatment because of anorexia. Conclusion We found that pirfenidone was better tolerated in patients with milder disease symptoms, as indicated by their baseline CPI, %FVC and %DLCO, and that patients in the tolerant group could benefit from the use of pirfenidone.

Original languageEnglish
Pages (from-to)2835-2841
Number of pages7
JournalInternal Medicine
Volume54
Issue number22
DOIs
Publication statusPublished - Nov 15 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Fingerprint

Dive into the research topics of 'Ecomposite physiologic index, percent forced vital capacity and percent diffusing capacity for carbon monoxide could be predictors of pirfenidone tolerability in patients with idiopathic pulmonary fibrosis'. Together they form a unique fingerprint.

Cite this