Early ductal lesions of pancreatic carcinogenesis in animals and humans

Yoichi Konishi, Kazuhiro Mizumoto, Shunji Kitazawa, Toshifumi Tsujiuchi, Masahiro Tsutsumi, Toshiki Kamano

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Two cases of human early pancreatic duct adenocarcinoma were presented, and ductal lesions observed histologically were compared to those induced in hamsters using a rapid-production model of pancreatic carcinoma. In human cases, direct histologic evidence was obtained to suggest that cancerous changes arose from duct epithelial cell hyperplasia, because lesions of hyperplasia and carcinoma coexisted in continuity. In hamster serialkilling studies, it was suggested that carcinoma developed through atypical ductal hyperplasia.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalInternational Journal of Pancreatology
Issue number1-3
Publication statusPublished - Aug 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Endocrinology
  • Oncology


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