TY - JOUR
T1 - Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy
AU - Nakatake, Shunji
AU - Murakami, Yusuke
AU - Funatsu, Jun
AU - Koyanagi, Yoshito
AU - Akiyama, Masato
AU - Momozawa, Yukihide
AU - Ishibashi, Tatsuro
AU - Sonoda, Koh Hei
AU - Ikeda, Yasuhiro
N1 - Funding Information:
Funding This work was supported by a Japanese Ministry of Education, Culture, Sports, Science, and Technology grant (no. 16H06268 to YM), a Japan Intractable Disease Research Foundation grant (to YM), a Japanese Retinitis Pigmentosa Society grant (to YM), and a Rohto Award (to YM).
Publisher Copyright:
© Springer-Verlag GmbH Germany, part of Springer Nature 2019.
PY - 2019/6
Y1 - 2019/6
N2 - Purpose The purpose of the study was to investigate the characteristics of the parafoveal cone density changes in patients with retinitis pigmentosa (RP) using adaptive optics scanning laser ophthalmoscopy (AO-SLO). Methods A total of 14 eyes of RP patients and 10 eyes of control subjects were examined. High-resolution images of cone photoreceptor cells were obtained with a Canon AO-SLO system in the four retinal regions of the superior, inferior, temporal, and nasal areas located 1.0 mm from the central fovea. The relationships of cone density with optical coherence tomography (OCT) findings and the visual sensitivity of the static perimetry tests were analyzed in RP patients. Results The averaged cone densities in RP patients were decreased at 1.0 mm eccentricity from the fovea (11,899 cells/mm2) compared with those in control subjects (16,647 cells/mm2; P < 0.01). The cone density was substantially decreased even in RP patients with an intact interdigitation zone at the examined area (12,865 cells/mm2; P < 0.01 vs. controls) and preserved visual sensitivity with > 35 dB (13,019 cells/mm2; P < 0.001 vs. controls). Conclusions In RP, cone photoreceptor cell loss occurred in the parafoveal region with a preserved EZ/IZ or visual sensitivity. AO-SLO may be a useful modality to detect early changes of cone photoreceptor cells in RP patients.
AB - Purpose The purpose of the study was to investigate the characteristics of the parafoveal cone density changes in patients with retinitis pigmentosa (RP) using adaptive optics scanning laser ophthalmoscopy (AO-SLO). Methods A total of 14 eyes of RP patients and 10 eyes of control subjects were examined. High-resolution images of cone photoreceptor cells were obtained with a Canon AO-SLO system in the four retinal regions of the superior, inferior, temporal, and nasal areas located 1.0 mm from the central fovea. The relationships of cone density with optical coherence tomography (OCT) findings and the visual sensitivity of the static perimetry tests were analyzed in RP patients. Results The averaged cone densities in RP patients were decreased at 1.0 mm eccentricity from the fovea (11,899 cells/mm2) compared with those in control subjects (16,647 cells/mm2; P < 0.01). The cone density was substantially decreased even in RP patients with an intact interdigitation zone at the examined area (12,865 cells/mm2; P < 0.01 vs. controls) and preserved visual sensitivity with > 35 dB (13,019 cells/mm2; P < 0.001 vs. controls). Conclusions In RP, cone photoreceptor cell loss occurred in the parafoveal region with a preserved EZ/IZ or visual sensitivity. AO-SLO may be a useful modality to detect early changes of cone photoreceptor cells in RP patients.
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U2 - 10.1007/S00417-019-04307-0
DO - 10.1007/S00417-019-04307-0
M3 - Article
C2 - 30937533
AN - SCOPUS:85066163687
SN - 0721-832X
VL - 257
SP - 1169
EP - 1181
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 6
ER -