Abstract
Background: Physiological significance of plasmalogen homeostasis remains unknown. Results: Elevation of plasmalogens reduced cholesterol synthesis by enhancing degradation of squalene monooxygenase (SQLE), whereas SQLE was stabilized in the absence of plasmalogens. Conclusion: Plasmalogens regulate cholesterol synthesis by modulating the stability of SQLE. Significance: SQLE stability is modulated in response to the cellular level of plasmalogens, in addition to the acute changes of cholesterol level.
| Original language | English |
|---|---|
| Pages (from-to) | 28822-28833 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 48 |
| DOIs | |
| Publication status | Published - Nov 27 2015 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology