Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma

Kotaro Shide; Hideho Henzan; Koji Nagafuji; Kenichi Aoki; Toshihiro Miyamoto; Kazuya Shimoda; Yukumasa Kazuyama; Koichi Ohshima; Hisashi Gondo; Mine Harada

doi:10.1002/jmv.10374

Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma

Kotaro Shide, Hideho Henzan, Koji Nagafuji, Kenichi Aoki, Toshihiro Miyamoto, Kazuya Shimoda, Yukumasa Kazuyama, Koichi Ohshima, Hisashi Gondo, Mine Harada

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Journal of Medical Virology
Volume	70
Issue number	1
DOIs	https://doi.org/10.1002/jmv.10374
Publication status	Published - May 1 2003

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.10374

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abstract = "We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.",

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AU - Shide, Kotaro

AU - Henzan, Hideho

AU - Nagafuji, Koji

AU - Aoki, Kenichi

AU - Miyamoto, Toshihiro

AU - Shimoda, Kazuya

AU - Kazuyama, Yukumasa

AU - Ohshima, Koichi

AU - Gondo, Hisashi

AU - Harada, Mine

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AB - We treated a 73-year-old man who developed a pyothorax-associated pleural lymphoma after a 52-year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B-cell type. Epstein-Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real-time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax-associated lymphoma.

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Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma

Abstract

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