Dynamics of cancer progression

Franziska Michor, Yoh Iwasa, Martin A. Nowak

Research output: Contribution to journalReview articlepeer-review

327 Citations (Scopus)


Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical equations. Cancer arises as a consequence of somatic evolution. Therefore, a mathematical approach can be used to understand the process of cancer initiation and progression. But what are the fundamental principles that govern the dynamics of activating oncogenes and inactivating tumour-suppressor genes in populations of reproducing cells? Also, how does a quantitative theory of somatic mutation and selection help us to evaluate the role of genetic instability?

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalNature Reviews Cancer
Issue number3
Publication statusPublished - Mar 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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