TY - GEN
T1 - Dynamics in the folding of long DNA chain under strong flow
AU - Saito, Takuya
AU - Sakaue, Takahiro
AU - Kaneko, Daiji
AU - Washizu, Masao
AU - Oana, Hidehiro
PY - 2008/12/1
Y1 - 2008/12/1
N2 - This paper presents the study about the dynamics in the folding of long DNA under strong flow. Di- rect observation of the folding process of the tethered DNA molecule induced by adding a condensing agent is demonstrated using a microfluidic device, and this theoretical interpretation of the process is provided. From the direct observation, it is found that the fold- ing dynamics typically exhibits characteristic three stages: (i) initial rapid compaction, (ii) slowing-down, (iii) sudden speed-up. Such a notable feature pin- points a nonequilibrium flow effect and can be inter- preted by a simple theory, which takes account of the nonuniformity of the tethered chain stretched by flow.
AB - This paper presents the study about the dynamics in the folding of long DNA under strong flow. Di- rect observation of the folding process of the tethered DNA molecule induced by adding a condensing agent is demonstrated using a microfluidic device, and this theoretical interpretation of the process is provided. From the direct observation, it is found that the fold- ing dynamics typically exhibits characteristic three stages: (i) initial rapid compaction, (ii) slowing-down, (iii) sudden speed-up. Such a notable feature pin- points a nonequilibrium flow effect and can be inter- preted by a simple theory, which takes account of the nonuniformity of the tethered chain stretched by flow.
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U2 - 10.1109/MHS.2008.4752434
DO - 10.1109/MHS.2008.4752434
M3 - Conference contribution
AN - SCOPUS:62449126103
SN - 9781424429196
T3 - 2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008
SP - 118
EP - 123
BT - 2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, with Symposium on "COE for Education and Research of Micro-Nano Mechatronics"
T2 - 2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, with Symposium on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "System Cell Engineering by Multi-scale Manipulation"
Y2 - 6 November 2008 through 9 November 2008
ER -