TY - JOUR
T1 - "Dynamic" molecular recognition and chirality segregation utilizing concepts of molecular machines and molecular assemblies
AU - Shinkai, Seiji
N1 - Funding Information:
I thank all the staff, postdoctoral fellows, and students at Nagasaki University, Kyushu University, and Sojo University and researchers at Japan Science and Technology Agency-supported National Projects. Thanks to their ingenuous inspirations and all-out efforts, the fruitful and stimulating results summarized in this review article have been achieved.
Publisher Copyright:
© 2019 The Japan Academy.
PY - 2019
Y1 - 2019
N2 - The need to measure the concentration of selected ions and small organic molecules in both in vivo and in vitro processes is continuously increasing beyond the borders of various research fields. This need has been fulfilled using "host-guest chemistry", or in general, by the use of "molecular recognition". The basic idea in these research fields was derived from the 1: 1 host-guest interaction based on the "key-and-lock" concept. However, we have experienced that only with this classical concept, more precise, higher-order recognition faces serious difficulty. In this review article, I wish to explain that the introduction of two new concepts, i.e., the dynamic action of molecular systems and the amplification effect of molecular assemblies, overcame the limitation of the "key-and-lock" concept. In fact, we have found that even "complete" chirality segregation can be achieved under optimal conditions.
AB - The need to measure the concentration of selected ions and small organic molecules in both in vivo and in vitro processes is continuously increasing beyond the borders of various research fields. This need has been fulfilled using "host-guest chemistry", or in general, by the use of "molecular recognition". The basic idea in these research fields was derived from the 1: 1 host-guest interaction based on the "key-and-lock" concept. However, we have experienced that only with this classical concept, more precise, higher-order recognition faces serious difficulty. In this review article, I wish to explain that the introduction of two new concepts, i.e., the dynamic action of molecular systems and the amplification effect of molecular assemblies, overcame the limitation of the "key-and-lock" concept. In fact, we have found that even "complete" chirality segregation can be achieved under optimal conditions.
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U2 - 10.2183/PJAB.95.040
DO - 10.2183/PJAB.95.040
M3 - Review article
C2 - 31827017
AN - SCOPUS:85076490996
SN - 0386-2208
VL - 95
SP - 590
EP - 601
JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences
JF - Proceedings of the Japan Academy Series B: Physical and Biological Sciences
IS - 10
ER -