Dynamic behavior of enzymatic system realizing two-factor model

Masahiro Okamoto, Atsuko Katsurayama, Michiko Tsukiji, Yoichi Aso, Katsuya Hayashi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


It has been shown that the two-factor model, introduced by Rosen for biological automata, could be realized at a molecular level by an enzymatic conjugate system. This system was applied to several metabolic regulatory models, and the dynamic behaviors were followed by computer simulation. It was revealed that the feedback system including the two-factor realizing system as a control element can maintain the stationary value of end product at a desired level against an external perturbation.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalJournal of Theoretical Biology
Issue number1
Publication statusPublished - Mar 7 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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