Duodenal adenomatosis in Japanese patients with familial adenomatous polyposis

Yuji Maehata, Motohiro Esaki, Minako Hirahashi, Takanari Kitazono, Takayuki Matsumoto

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Duodenal adenomatosis is the most frequent extracolonic manifestation of familial adenomatous polyposis (FAP), and duodenal cancer has been assumed to be the second most significant cause of death in patients with the disease. To stratify the risk of duodenal cancer, Spigelman's classification was proposed for the staging of duodenal adenomatosis. According to Western guidelines, patients with stage IV of the classification are candidates for prophylactic duodenectomy. Since our institutional experience disclosed only 2% of duodenal or ampullary cancers among 130 patients with FAP, and because most duodenal adenomatosis remains unchanged under endoscopic surveillance, it seems likely that aggressive endoscopic or surgical removal is unnecessary for most FAP patients with duodenal adenomatosis. In the present article, we demonstrate our data and present our strategy for duodenal adenomatosis of FAP.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalDigestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Publication statusPublished - Apr 1 2014

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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