Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist

Kyoko Fukunaga; Takahiro Tsukida; Hideki Moriyama; Hirosato Kondo

doi:10.1016/S0960-894X(01)00430-9

Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist

Kyoko Fukunaga, Takahiro Tsukida, Hideki Moriyama, Hirosato Kondo

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We have designed a series of simple rigid compounds (2) having a phenyl ring attached to three essential groups necessary for selectin binding, i.e., a fucose unit, a carboxylic acid, and the hydrophobic part. In this series of compound 2, 2a exhibited strong inhibitory activity in in vitro P-selectin mediated cell adhesion assay. The novel type of compound 2a would be a potential lead compound for selectin antagonist.

Original language	English
Pages (from-to)	2365-2367
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	17
DOIs	https://doi.org/10.1016/S0960-894X(01)00430-9
Publication status	Published - Sept 3 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00430-9

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AU - Kondo, Hirosato

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Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist

Abstract

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