Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair

Keijiro Ishikawa; Masato Akiyama; Kenichiro Mori; Takahito Nakama; Shoji Notomi; Shintaro Nakao; Ri-Ichiro Kohno; Atsunobu Takeda; Koh-Hei Sonoda

doi:10.1016/j.ajo.2021.07.028

Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair

Keijiro Ishikawa, Masato Akiyama, Kenichiro Mori, Takahito Nakama, Shoji Notomi, Shintaro Nakao, Ri-Ichiro Kohno, Atsunobu Takeda, Koh-Hei Sonoda

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).

DESIGN: Nation-wide, multi-center, clinical cohort study based on registry data.

METHODS: Subjects: The 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017.

PROCEDURES: Associations of 13 baseline characteristics and eight surgical procedures with ERM formation were evaluated using univariate analysis. We conducted a propensity score-matched analysis for the significantly associated clinical factor(s).

MAIN OUTCOME MEASURES: ERM formation after six months of vitrectomy.

RESULTS: ERM had developed in 104 cases (4.6%) by six months. We found that a drainage retinotomy was significantly associated with ERM after multiple testing correction (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.50-3.31, P < 0.001). In the propensity score-matched analysis (N = 492 in each group), we confirmed a significant difference in the incidence of ERM after six months of vitrectomy (8.3% and 2.6% in cases with and without drainage retinotomy, respectively; OR = 3.35, 95% CI 1.77-6.33; P < 0.001).

CONCLUSIONS: Eyes treated with PPV combined with drainage retinotomy are more likely to develop ERM postoperatively.

Original language	English
Journal	American journal of ophthalmology
DOIs	https://doi.org/10.1016/j.ajo.2021.07.028
Publication status	E-pub ahead of print - Jul 30 2021

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10.1016/j.ajo.2021.07.028

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@article{3ab92c54dc8e4a7781117cd7befd88b8,

title = "Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair",

abstract = "PURPOSE: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).DESIGN: Nation-wide, multi-center, clinical cohort study based on registry data.METHODS: Subjects: The 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017.PROCEDURES: Associations of 13 baseline characteristics and eight surgical procedures with ERM formation were evaluated using univariate analysis. We conducted a propensity score-matched analysis for the significantly associated clinical factor(s).MAIN OUTCOME MEASURES: ERM formation after six months of vitrectomy.RESULTS: ERM had developed in 104 cases (4.6%) by six months. We found that a drainage retinotomy was significantly associated with ERM after multiple testing correction (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.50-3.31, P < 0.001). In the propensity score-matched analysis (N = 492 in each group), we confirmed a significant difference in the incidence of ERM after six months of vitrectomy (8.3% and 2.6% in cases with and without drainage retinotomy, respectively; OR = 3.35, 95% CI 1.77-6.33; P < 0.001).CONCLUSIONS: Eyes treated with PPV combined with drainage retinotomy are more likely to develop ERM postoperatively.",

author = "Keijiro Ishikawa and Masato Akiyama and Kenichiro Mori and Takahito Nakama and Shoji Notomi and Shintaro Nakao and Ri-Ichiro Kohno and Atsunobu Takeda and Koh-Hei Sonoda",

note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",

year = "2021",

month = jul,

day = "30",

doi = "10.1016/j.ajo.2021.07.028",

language = "English",

journal = "American journal of ophthalmology",

issn = "0002-9394",

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T1 - Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair

AU - Ishikawa, Keijiro

AU - Akiyama, Masato

AU - Mori, Kenichiro

AU - Nakama, Takahito

AU - Notomi, Shoji

AU - Nakao, Shintaro

AU - Kohno, Ri-Ichiro

AU - Takeda, Atsunobu

AU - Sonoda, Koh-Hei

PY - 2021/7/30

Y1 - 2021/7/30

N2 - PURPOSE: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).DESIGN: Nation-wide, multi-center, clinical cohort study based on registry data.METHODS: Subjects: The 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017.PROCEDURES: Associations of 13 baseline characteristics and eight surgical procedures with ERM formation were evaluated using univariate analysis. We conducted a propensity score-matched analysis for the significantly associated clinical factor(s).MAIN OUTCOME MEASURES: ERM formation after six months of vitrectomy.RESULTS: ERM had developed in 104 cases (4.6%) by six months. We found that a drainage retinotomy was significantly associated with ERM after multiple testing correction (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.50-3.31, P < 0.001). In the propensity score-matched analysis (N = 492 in each group), we confirmed a significant difference in the incidence of ERM after six months of vitrectomy (8.3% and 2.6% in cases with and without drainage retinotomy, respectively; OR = 3.35, 95% CI 1.77-6.33; P < 0.001).CONCLUSIONS: Eyes treated with PPV combined with drainage retinotomy are more likely to develop ERM postoperatively.

AB - PURPOSE: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).DESIGN: Nation-wide, multi-center, clinical cohort study based on registry data.METHODS: Subjects: The 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017.PROCEDURES: Associations of 13 baseline characteristics and eight surgical procedures with ERM formation were evaluated using univariate analysis. We conducted a propensity score-matched analysis for the significantly associated clinical factor(s).MAIN OUTCOME MEASURES: ERM formation after six months of vitrectomy.RESULTS: ERM had developed in 104 cases (4.6%) by six months. We found that a drainage retinotomy was significantly associated with ERM after multiple testing correction (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.50-3.31, P < 0.001). In the propensity score-matched analysis (N = 492 in each group), we confirmed a significant difference in the incidence of ERM after six months of vitrectomy (8.3% and 2.6% in cases with and without drainage retinotomy, respectively; OR = 3.35, 95% CI 1.77-6.33; P < 0.001).CONCLUSIONS: Eyes treated with PPV combined with drainage retinotomy are more likely to develop ERM postoperatively.

U2 - 10.1016/j.ajo.2021.07.028

DO - 10.1016/j.ajo.2021.07.028

M3 - Article

C2 - 34339662

SN - 0002-9394

JO - American journal of ophthalmology

JF - American journal of ophthalmology

ER -

Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair

Abstract

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