Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells

Biochemistry, Genetics and Molecular Biology

• Statin 100%
• Atorvastatin 66%
• Membrane Depolarization 50%
• Mitochondrial Membrane 50%
• Kinase 33%
• Protein 33%
• Caspase 3 33%
• Mitochondrial Membrane Potential 33%
• Cell Death 33%
• Geranylgeranyl Pyrophosphate 33%
• Pravastatin 16%
• Anabolism 16%
• Apoptosis 16%
• down Regulation 16%
• Lipid 16%
• G Protein 16%
• Reductase 16%
• Cell Viability 16%
• Caspase 16%
• Fasudil 16%
• Cell Damage 16%
• Y-27632 16%
• Exoenzyme 16%
• Farnesyl Pyrophosphate 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 66%
• Atorvastatin 66%
• Western Blot 33%
• Caspase 3 33%
• Cell Death 33%
• Statin (Protein) 33%
• Mevalonic Acid 33%
• Geranylgeranyl Pyrophosphate 33%
• RhoA Guanine Nucleotide Binding Protein 33%
• Pravastatin 16%
• Injury 16%
• Protein 16%
• Oxidoreductase 16%
• Apoptosis 16%
• Lipid 16%
• Toxin 16%
• Guanine Nucleotide Binding Protein 16%
• Enzyme-Linked Immunosorbent Assay 16%
• Etiology 16%
• Rho Kinase 16%
• Rho Kinase Inhibitor 16%
• Caspase 16%
• Hepatotoxicity 16%
• Fasudil 16%
• Viability Assay 16%
• Exoenzyme C3 16%
• Farnesyl Diphosphate 16%