TY - JOUR
T1 - Dopamine receptor agonists and antagonists enhance ATP-activated currents
AU - Inoue, Kazuhide
AU - Nakazawa, Ken
AU - Watano, Tomokazu
AU - Ohara-Imaizumi, Mica
AU - Fujimori, Kannosuke
AU - Takanaka, Akira
PY - 1992/5/14
Y1 - 1992/5/14
N2 - The effects of dopamine and related compounds on ATP-activated channels were investigated in pheochromocytoma PC12 cells. Dopamine (10 μM) enhanced an inward current activated by 100 μM ATP. A similar enhancement of the ATP-activated current was observed with apomorphine (10 μM), a non-selective dopamine receptor agonist, with (+)-SKF-38393 (10 μM), a selective dopamine D1 receptor agonist, and with (-)-quinpirole (10 μM), a selective dopamine D2 receptor agonist. Moreover, (+)-SCH-23390 (30 μM), a dopamine D1 receptor antagonist, and (-)-sulpiride (30 μM), a dopamine D2 receptor antagonist, also enhanced the ATP-activated current. The results suggest that ATP-activated channels are modulated by dopaminergic mechanisms, and that this modulation cannot be attributed to any single class of dopamine receptors.
AB - The effects of dopamine and related compounds on ATP-activated channels were investigated in pheochromocytoma PC12 cells. Dopamine (10 μM) enhanced an inward current activated by 100 μM ATP. A similar enhancement of the ATP-activated current was observed with apomorphine (10 μM), a non-selective dopamine receptor agonist, with (+)-SKF-38393 (10 μM), a selective dopamine D1 receptor agonist, and with (-)-quinpirole (10 μM), a selective dopamine D2 receptor agonist. Moreover, (+)-SCH-23390 (30 μM), a dopamine D1 receptor antagonist, and (-)-sulpiride (30 μM), a dopamine D2 receptor antagonist, also enhanced the ATP-activated current. The results suggest that ATP-activated channels are modulated by dopaminergic mechanisms, and that this modulation cannot be attributed to any single class of dopamine receptors.
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U2 - 10.1016/0014-2999(92)90049-A
DO - 10.1016/0014-2999(92)90049-A
M3 - Article
C2 - 1383001
AN - SCOPUS:0026563028
SN - 0014-2999
VL - 215
SP - 321
EP - 324
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -