Domino liver transplantation from a living related donor

Takashi Nishizaki, Keishi Kishikawa, Tomoharu Yoshizumi, Hideaki Uchiyama, Shinji Okano, Toru Ikegami, Koji Hashimoto, Kenichi Nomoto, Mitsuo Shimada, Katsuhiko Yanaga, Kenji Takenaka, Keizo Sugimachi, Yukio Ando, Masayuki Ando

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background. Although domino liver transplantations (OLT) from cadaveric donors have been performed in about 50 cases since 1995, only one case in the Japanese literature has been reported on a domino OLT from a living related donor. The difficulties of the later surgery lie in the small size of the graft volume and the short length of the vascular cuffs in the graft. Methods. The left lobe graft was procured from a 43-year-old younger brother of a familial amyloidotic polyneuropathy (FAP) patient. Next, the left lobe graft (510 g, 44% of the estimated standard liver volume of the FAP patient) was implanted into the 48-year-old female FAP patient. At surgery for the FAP patient, a sufficient length of the vascular cuffs was secured by an extended left lobe resection, although the right lobe graft was able to maintain sufficient vascular cuffs. The right lobe graft (720 g, 54% of the recipient's estimated standard liver volume) was then implanted in the 43-year-old male patient with liver cirrhosis and hepatocellular carcinoma (stage IV-A). Results. The two recipients were discharged from the hospital 1 month after OLT. At 7 months after OLT, they are both doing well and the domino recipient is free of any tumor recurrence. Conclusion. A domino OLT from the living related donor can therefore be done safely when tention is paid to the graft volume and the length of the vascular cuffs for anastomosis.

Original languageEnglish
Pages (from-to)1236-1239
Number of pages4
Issue number8
Publication statusPublished - Oct 27 2000

All Science Journal Classification (ASJC) codes

  • Transplantation


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