DNA replication stress and cancer chemotherapy

Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)


DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also referred to as DNA replication stress (DRS). When we consider therapeutic approaches for tumors, it is important to exploit the differences in DRS between tumor and normal cells. In this review, we introduce the current understanding of DRS in tumors and discuss the underlying mechanism of cancer therapy from the aspect of DRS.

Original languageEnglish
Pages (from-to)264-271
Number of pages8
JournalCancer Science
Issue number2
Publication statusPublished - Feb 2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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