@article{5700a893960c4e73a19d41420d492df3,
title = "DNA replication stress and cancer chemotherapy",
abstract = "DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also referred to as DNA replication stress (DRS). When we consider therapeutic approaches for tumors, it is important to exploit the differences in DRS between tumor and normal cells. In this review, we introduce the current understanding of DRS in tumors and discuss the underlying mechanism of cancer therapy from the aspect of DRS.",
author = "Hiroyuki Kitao and Makoto Iimori and Yuki Kataoka and Takeshi Wakasa and Eriko Tokunaga and Hiroshi Saeki and Eiji Oki and Yoshihiko Maehara",
note = "Funding Information: Y.K. and T.W. are employees of Taiho Pharmaceutical Co. Ltd. H.K. and M.I. are staff members of the Joint Research Department funded by Taiho Pharmaceutical Co. Ltd. at Kyushu University. Y.M. reports receiving commercial research grants from Taiho Pharmaceutical Co. Ltd., Yakult Honsha Co. Ltd., Chugai Pharmaceutical Co. Ltd., and Ono Pharmaceutical Co. Ltd. E.O. and Y.M. report receiving honoraria from Taiho Pharmaceutical Co. Ltd. The other authors have no conflict of interest. Funding Information: This study was supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to H. Kitao, Japan Society for the Promotion of Science KAKENHI grant no. 17H03598). Publisher Copyright: {\textcopyright} 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.",
year = "2018",
month = feb,
doi = "10.1111/cas.13455",
language = "English",
volume = "109",
pages = "264--271",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "2",
}
