TY - JOUR
T1 - DNA repair in hyperthermophilic and hyperradioresistant microorganisms
AU - Ishino, Yoshizumi
AU - Narumi, Issay
N1 - Funding Information:
This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan [grant numbers 21113005 , 23310152 , and 26242075 to Y. I., 19380054 , 22580098 , and 26450103 to I.N.], and also a grant from the INOUE ENRYO Memorial Foundation for Promoting Sciences (I.N.) .
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The genome of a living cell is continuously under attack by exogenous and endogenous genotoxins. Especially, life at high temperature inflicts additional stress on genomic DNA, and very high rates of potentially mutagenic DNA lesions, including deamination, depurination, and oxidation, are expected. However, the spontaneous mutation rates in hyperthermophiles are similar to that in Escherichia coli, and it is interesting to determine how the hyperthermophiles preserve their genomes under such grueling environmental conditions. In addition, organisms with extremely radioresistant phenotypes are targets for investigating special DNA repair mechanisms in extreme environments. Multiple DNA repair mechanisms have evolved in all organisms to ensure genomic stability, by preventing impediments that result in genome destabilizing lesions.
AB - The genome of a living cell is continuously under attack by exogenous and endogenous genotoxins. Especially, life at high temperature inflicts additional stress on genomic DNA, and very high rates of potentially mutagenic DNA lesions, including deamination, depurination, and oxidation, are expected. However, the spontaneous mutation rates in hyperthermophiles are similar to that in Escherichia coli, and it is interesting to determine how the hyperthermophiles preserve their genomes under such grueling environmental conditions. In addition, organisms with extremely radioresistant phenotypes are targets for investigating special DNA repair mechanisms in extreme environments. Multiple DNA repair mechanisms have evolved in all organisms to ensure genomic stability, by preventing impediments that result in genome destabilizing lesions.
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U2 - 10.1016/j.mib.2015.05.010
DO - 10.1016/j.mib.2015.05.010
M3 - Review article
C2 - 26056771
AN - SCOPUS:84931267057
SN - 1369-5274
VL - 25
SP - 103
EP - 112
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -
