DNA nanomachine switching improved by cationic comb-type copolymer

Won Choi Sung, Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike, Atsushi Maruyama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For the better applications and developments of DNA nanomachines, their responding kinetics, outputs, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in the operation conditions such as temperature, salt condition, and DNA strand concentration. In this study, we evaluated the effect of a cationic copolymer on the responses of a DNA-fueled nanomachine. We found that the copolymer increases quickness of the nanomachine under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nM range).

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalMacromolecular Symposia
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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