DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification

Akihiko Ono; Akira Ito; Taiga Suzuki; Masaki Yamaguchi; Yoshinori Kawabe; Masamichi Kamihira

doi:10.1016/j.jbiosc.2015.02.009

DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification

Akihiko Ono, Akira Ito, Taiga Suzuki, Masaki Yamaguchi, Yoshinori Kawabe, Masamichi Kamihira

Molecular and Biochemical Systems Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	Journal of Bioscience and Bioengineering
Volume	120
Issue number	4
DOIs	https://doi.org/10.1016/j.jbiosc.2015.02.009
Publication status	Published - Oct 1 2015

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1016/j.jbiosc.2015.02.009

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title = "DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification",

abstract = "We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.",

author = "Akihiko Ono and Akira Ito and Taiga Suzuki and Masaki Yamaguchi and Yoshinori Kawabe and Masamichi Kamihira",

note = "Funding Information: This work was supported in part by Grant-in-Aid for Scientific Research on Innovative Areas (No. 26119714 ) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT). Publisher Copyright: {\textcopyright} 2015 The Society for Biotechnology, Japan.",

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T1 - DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification

AU - Ono, Akihiko

AU - Ito, Akira

AU - Suzuki, Taiga

AU - Yamaguchi, Masaki

AU - Kawabe, Yoshinori

AU - Kamihira, Masamichi

N1 - Funding Information: This work was supported in part by Grant-in-Aid for Scientific Research on Innovative Areas (No. 26119714 ) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT). Publisher Copyright: © 2015 The Society for Biotechnology, Japan.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.

AB - We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.

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ER -

DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification

Abstract

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