Diverse roles of macrophages in intraocular neovascular diseases: A review

Ye Di Zhou, Shigeo Yoshida, Ying Qian Peng, Yoshiyuki Kobayashi, Lu Si Zhang, Luo Sheng Tang

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


● Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.

Original languageEnglish
Pages (from-to)1902-1908
Number of pages7
JournalInternational Journal of Ophthalmology
Issue number12
Publication statusPublished - Dec 18 2017

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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