TY - JOUR
T1 - Diverse effects of tumor necrosis factor-α on three subclones from human myelomonocytic leukemia cell line ME-1 exhibiting different differentiation stages
AU - Yanagisawa, Kohsuke
AU - Watanabe, Ichiro
AU - Inoue, Yasuhiro
AU - Horiuchi, Takahiko
AU - Hasegawa, Hitoshi
AU - Yasukawa, Masaki
AU - Fujita, Shigeru
PY - 1996
Y1 - 1996
N2 - The effects of tumor necrosis factor-α (TNF-α) were examined in three subclone cells from human myelomonocytic leukemia cell line ME-1. These three subclone cells exhibit different differentiation stages of the myelomonocytic lineage. TNF-α exerted a growth-suppressive effect on the least mature subclone cells, ME-F2 cells. On the other hand, TNF-α induced the most mature ME-F1 cells and intermediate ME-F3 cells to differentiate along the monocytic pathway. TNF-α also enhanced interferon-γ (IFN-γ)-induced complement C2 production by ME-F1 and ME-F3 cells but did not affect production by differentiated ME-F1 and ME-F3 cells. These results suggest that the diversity of the effects of TNF on subclone cells from ME-1 depends on the stage of cell differentiation.
AB - The effects of tumor necrosis factor-α (TNF-α) were examined in three subclone cells from human myelomonocytic leukemia cell line ME-1. These three subclone cells exhibit different differentiation stages of the myelomonocytic lineage. TNF-α exerted a growth-suppressive effect on the least mature subclone cells, ME-F2 cells. On the other hand, TNF-α induced the most mature ME-F1 cells and intermediate ME-F3 cells to differentiate along the monocytic pathway. TNF-α also enhanced interferon-γ (IFN-γ)-induced complement C2 production by ME-F1 and ME-F3 cells but did not affect production by differentiated ME-F1 and ME-F3 cells. These results suggest that the diversity of the effects of TNF on subclone cells from ME-1 depends on the stage of cell differentiation.
UR - http://www.scopus.com/inward/record.url?scp=0029741984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029741984&partnerID=8YFLogxK
U2 - 10.1089/jir.1996.16.685
DO - 10.1089/jir.1996.16.685
M3 - Article
C2 - 8887052
AN - SCOPUS:0029741984
SN - 1079-9907
VL - 16
SP - 685
EP - 693
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
IS - 9
ER -