Diurnal variation in secretory immunoglobulin A concentration

Zhongfeng Liu, Michihiko Otonari, Seiko Naito, Shin Yasuda, Hideyuki Tanaka, Hiroshi Yoshioka, Masato Oyabu, Takuro Tobina, Ryou Kanda, Hiroaki Tanaka, Munehiro Shindo, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The aim of this study was to investigate the effect of time of day on secretory immunoglobulin A (sIgA). Six males participated in this study. Saliva samples were collected for each subject at 06:00, 06:30, 07:00, 07:30, 11:30, 18:00, 22:30 and 06:00 next morning on both routine diet day and prescribed diet day. SIgA concentration was determined by an enzyme linked immunosorbent assay, and total saliva protein concentration was determined by BCA protein kit. There was no significant diurnal variation for saliva flow rate in each day. SIgA concentration and secretion rate were high in the morning and low in the afternoon and evening on both days, and the levels of sIgA concentration at 18:00 and 22:30 were significantly lower than that at 06:00 next morning on the prescribed diet day. Both sIgA concentration and secretion rate had no significant difference between routine diet day and prescribed diet day. The levels of total saliva protein concentration and secretion rate at 18:00 were higher in routine diet day than in prescribed diet day. These results suggested that sIgA concentration showed diurnal variation on prescribed diet day.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalJournal of the Faculty of Agriculture, Kyushu University
Issue number1-2
Publication statusPublished - Oct 2003

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science


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