Disuse Atrophy of the Aortic Valve After Left Ventricular Assist Device Implantation

Tomoki Ushijima, Yoshihisa Tanoue, Tomomi Ide, Shinji Okano, Yoshinao Oda, Ryuji Tominaga

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 31-year-old woman underwent implantation of a DuraHeart left ventricular assist device as bridge to transplantation. Aortic insufficiency was not observed before implantation but developed after implantation and became severe approximately 2 years later. Macroscopically, the aortic valve excised during heart transplantation showed no morphologic alteration. Microscopically, the collagen fibers in the fibrosa layer and the elastic fibers in the ventricularis layer of the valve leaflets were reduced in number, with irregular arrangement. These characteristics can be explained by a disuse atrophic change, and may lead to a better understanding of the mechanism underlying the development of aortic insufficiency.

Original languageEnglish
Pages (from-to)742-744
Number of pages3
JournalAnnals of Thoracic Surgery
Issue number2
Publication statusPublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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