Distribution of proglucagon mRNA and GLP-1 in the brainstem of chicks

Tetsuya Tachibana, Kohzy Hiramatsu, Mitsuhiro Furuse, Shin Hasegawa, Fumiaki Yoshizawa, Kunio Sugahara

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Glucagon-like peptide-1 (GLP-1), structurally similar to glucagon, synthesized from the precursor proglucagon, is a well known anorexigenic peptide in the brain of several animal species. However, there are no previous reports concerning GLP-1-containing neurons in the chick brain. The aim of the present study was to investigate the distribution of proglucagon mRNA and GLP-1-immunoreactive (GLI) perikarya in various regions of the chick brain. We detected proglucagon mRNA in the brainstem, and to a lesser extent in the telencephalon. In the brainstem, a study using immunohistochemistry revealed that GLI perikarya were present in the nucleus motorius nervi facialis pars dosalis, nucleus motoris dorsalis nervi vagi and nucleus tractus solitarii. Furthermore, we found that proglucagon mRNA expression in the brainstem decreased after 24 h fasting. The present findings support the idea that endogenous GLP-1 is involved in feeding behavior of chicks.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Issue number2
Publication statusPublished - Feb 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology


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