Distinct roles of microglia and monocytes in central nervous system inflammation and degeneration

Ryo Yamasaki

doi:10.1111/cen3.12162

Distinct roles of microglia and monocytes in central nervous system inflammation and degeneration

Ryo Yamasaki

Department of Neurogy

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Monocytes and microglia both originate from myeloid precursor cells and share common characteristics even after differentiation. Recent studies have shown functional differences between these cell types, indicating their unique roles in lesion formation in neurodegenerative diseases. The present review summarizes the functional characteristics of these "similar but different" macrophages in both health and disease.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Clinical and Experimental Neuroimmunology
Volume	5
Issue number	s1
DOIs	https://doi.org/10.1111/cen3.12162
Publication status	Published - Dec 1 2014

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Immunology
Immunology and Microbiology (miscellaneous)
Clinical Neurology

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10.1111/cen3.12162

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N2 - Monocytes and microglia both originate from myeloid precursor cells and share common characteristics even after differentiation. Recent studies have shown functional differences between these cell types, indicating their unique roles in lesion formation in neurodegenerative diseases. The present review summarizes the functional characteristics of these "similar but different" macrophages in both health and disease.

AB - Monocytes and microglia both originate from myeloid precursor cells and share common characteristics even after differentiation. Recent studies have shown functional differences between these cell types, indicating their unique roles in lesion formation in neurodegenerative diseases. The present review summarizes the functional characteristics of these "similar but different" macrophages in both health and disease.

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M3 - Review article

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JO - Clinical and Experimental Neuroimmunology

JF - Clinical and Experimental Neuroimmunology

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Distinct roles of microglia and monocytes in central nervous system inflammation and degeneration

Abstract

All Science Journal Classification (ASJC) codes

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