Disruption of klotho gene causes an abnormal energy homeostasis in mice

Kiyoshi Mori, Kensei Yahata, Masashi Mukoyama, Takayoshi Suganami, Hisashi Makino, Tetsuya Nagae, Hiroaki Masuzaki, Yoshihiro Ogawa, Akira Sugawara, Yo ichi Nabeshima, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


klotho mice, which genetically lack klotho gene expression, are characterized with various systemic phenotypes resembling human aging, and also with growth retardation. Here we show that klotho mice have a barely detectable amount of the white adipose tissue but their brown adipose tissue (BAT) is comparably preserved. Glucose tolerance and insulin sensitivity in klotho mice are increased compared to those in wild-type mice as revealed by intraperitoneal glucose and insulin tolerance tests. Uncoupling protein-1 gene expression of BAT and body temperature in klotho mice are lower than those in wild-type mice, suggesting that klotho mice have less energy expenditure than wild-type mice. Histological examination suggests that klotho mice possess less energy storage than wild-type mice with respect to glycogen in the liver and lipid in BAT. All these changes of parameters for energy homeostasis in klotho mice are very similar to those reported under food-restricted conditions. However, the amount of food intake is not different between klotho and wild-type mice when normalized for body weight. The present study elucidates the importance of klotho gene expression for the maintenance of normal energy homeostasis. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Nov 30 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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