Discriminate surface molecular recognition sites on a microporous substrate: A new approach

Mina Han, Ravi Kane, Masahiro Goto, Georges Belfort

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)


    A novel two-dimensional surface molecular imprinting method using water-in-oil emulsion photopolymerization on a microporous polypropylene substrate was developed and used to separate the bronchodilator, theophylline, from the mild stimulant, caffeine, both of similar chemical structure. Surface molecular recognition sites were generated that could discriminate between these two molecules with a concentration-dependent separation factor of 4.9 ± 0.8 for theophylline over caffeine at 0.2 mM (1:1 v/v) solution mixture. Besides demonstrating its proof of concept, the attractive features of this new imprinting method are the following: fewer imprint molecules are needed, it can be used to imprint from aqueous environments, postcrushing of the solid matrix is not needed, recognition sites are all near or at the surface reducing mass transfer limitations, and imprinting on synthetic microporous membranes (with convection and diffusion) instead of beads (with only diffusion) speeds up the process.

    Original languageEnglish
    Pages (from-to)4472-4477
    Number of pages6
    Issue number12
    Publication statusPublished - Jun 17 2003

    All Science Journal Classification (ASJC) codes

    • Organic Chemistry
    • Polymers and Plastics
    • Inorganic Chemistry
    • Materials Chemistry


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