Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases

Yoshiaki Shinden, Sayuri Akiyoshi, Hiroki Ueo, Syo Nambara, Tomoko Saito, Hisateru Komatsu, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Yuki Takano, Tomohiro Iguchi, Hidetoshi Eguchi, Keishi Sugimachi, Yuko Kijima, Hiroaki Ueo, Shoji Natsugoe, Koshi Mimori

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.

Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.

Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].

Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalAnticancer research
Issue number1
Publication statusPublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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