Diffusion-weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: Usefulness of detecting keratinoid substances in mature cystic teratomas

Tomohiro Nakayama, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kunishige Matake, Daisuke Kakihara, Shuji Matsuura, Hitoo Nakano, Hiroshi Honda

    Research output: Contribution to journalArticlepeer-review

    134 Citations (Scopus)

    Abstract

    Purpose: To elucidate whether apparent diffusion coefficient (ADC) values calculated from echo-planar diffusion-weighted MR imaging (EPDWI) are useful in the differential diagnosis of ovarian cystic masses. Materials and Methods: EPDWI was performed in 131 patients with ovarian cystic masses (54 mature cystic teratomas, 35 endometrial cysts, four other benign cysts, 14 benign neoplasms, and 24 malignant neoplasms). The areas of the highest signal intensity on EPDWI (b = 1000 seconds/mm2) and the lowest ADC values within the cystic component were evaluated. Results: On qualitative and quantitative analyses, mature cystic teratomas tended to show higher signal intensity and had areas of lower ADC values than endometrial cysts and other benign and malignant neoplasms (P < .005). In vitro scanning of the cystic contents of mature cystic teratomas confirmed that high signal on DWI or low ADC value was attributable to the keratinoid substance within the tumors. The difference in ADC between malignant and benign lesions were significant when mature cystic teratomas and endometrial cysts were included, but was not significant when they were excluded. Conclusion: The ADC value may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat.

    Original languageEnglish
    Pages (from-to)271-278
    Number of pages8
    JournalJournal of Magnetic Resonance Imaging
    Volume22
    Issue number2
    DOIs
    Publication statusPublished - Aug 2005

    All Science Journal Classification (ASJC) codes

    • Radiology Nuclear Medicine and imaging

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