Diffusion tensor studies dissociated two fronto-temporal pathways in the human memory system

Emi Takahashi, Kenichi Ohki, Dae Shik Kim

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Recent functional neuroimaging studies have shown that multiple cortical areas are involved in memory encoding and retrieval. However, the underlying anatomical connections among these memory-related areas in humans remain elusive due to methodological limitations. Diffusion tensor imaging (DTI) is a technique based on detecting the diffusion of water molecules from magnetic resonance images. DTI allows non-invasive mapping of anatomical connections and gives a comprehensive picture of connectivity throughout the entire brain. By combining functional magnetic resonance imaging (fMRI) and DTI, we show that memory-related areas in the left dorsolateral prefrontal cortex (DLPFC) and the left ventrolateral prefrontal cortex (VLPFC) each connect with memory-related areas in the left temporal cortex. This result suggests there are two pathways between prefrontal cortex and temporal cortex related to the human memory system.

Original languageEnglish
Pages (from-to)827-838
Number of pages12
Issue number2
Publication statusPublished - Jan 15 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience


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