Differential roles of carboxylated and uncarboxylated osteocalcin in prostate cancer growth

Yoshikazu Hayashi, Tomoyo Kawakubo-Yasukochi, Akiko Mizokami, Hiroshi Takeuchi, Seiji Nakamura, Masato Hirata

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Serum levels of osteocalcin (OC), a bone matrix non-collagenous protein secreted by osteoblasts, are correlated with pathological bone remodeling such as the bone metastasis of cancer, as well as physiological bone turnover. The pathological roles in prostate cancer growth of the two existing types of serum OC, γ-carboxylated (GlaOC) and lower- (or un-) carboxylated (GluOC), have not yet been discriminatively examined. In the present study, we demonstrate that normal prostate epithelial cell growth was promoted by both types of OC, while growth of cancer cells in the prostate was accelerated by GlaOC but suppressed by GluOC. We suggest that OC regulates prostate cancer growth depending on the γ-carboxylation, in part by triggering reduced phosphorylation of receptor tyrosine kinases.

Original languageEnglish
Pages (from-to)1605-1609
Number of pages5
JournalJournal of Cancer
Issue number12
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology


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