TY - JOUR
T1 - Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis
AU - Yoshimura, Takeru
AU - Sonoda, Koh Hei
AU - Miyazaki, Yoshiyuki
AU - Iwakura, Yoichiro
AU - Ishibashi, Tatsuro
AU - Yoshimura, Akihiko
AU - Yoshida, Hiroki
N1 - Funding Information:
The Ministry of Education, Science, Technology, Sports and Culture of Japan (to H.Y. and A.Y.); Japan Research Foundation for Clinical Pharmacology (to H.Y.); the Naito Foundation (H.Y.); the Takeda Science Foundation (to H.Y.).
PY - 2008/2
Y1 - 2008/2
N2 - IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.
AB - IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.
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U2 - 10.1093/intimm/dxm135
DO - 10.1093/intimm/dxm135
M3 - Article
C2 - 18156624
AN - SCOPUS:39049129395
SN - 0953-8178
VL - 20
SP - 209
EP - 214
JO - International immunology
JF - International immunology
IS - 2
ER -
