Differential modulation by μ- and θ-opioids on baroreceptor reflex in conscious rabbits

Kiyoshi Matsumura, Isao Abe, Mitsuhiro Tominaga, Takuya Tsuchihashi, Kazuo Kobayashi, Masatoshi Fujishima

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


We examined the role of central μ- and δ-opioids on both neurohormonal responses and baroreceptor reflex in conscious rabbits. Both intracerebroventricular [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin, a μ-selective agonist, and [D-Ala2,D-Leus5]-enkephalin, a δ-selective agonist, caused dose-related increases in arterial pressure and renal sympathetic nerve activity, whereas intravenous injection of the same maximum dose of these peptides as that used in the intracerebroventricular experiment did not cause any cardiovascular and neuronal responses. On the other hand, increases in plasma epinephrine, norepinephrine, and glucose levels induced by intracerebroventricular [D-Ala2, N-Me-Phe4,Gly5-ol]-enkephalin were significantly greater than those by [D-Ala2,D-Leu5]-enkephalin. Both enkephalins did not cause any responses in plasma renin activity, plasma vasopressin, and serum sodium and potassium concentrations. The sensitivity of the baroreceptor reflex control of renal sympathetic nerve activity using a logistic model was enhanced by a subpressor dose of intracerebroventricular [D-Ala2, N-Me-Phe4,Gly5-ol]-enkephalin (10 pmol/kg) but not by [D-Ala2,D-Leu5]-enkephalin. Conversely, a μ-selective dose of intravenous naloxone (0.1 mg/kg) attenuated baroreceptor reflex sensitivity. Intravenous naloxone methobromide, which has been shown not to cross the blood-brain barrier, did not change baroreceptor reflex sensitivity, suggesting that naloxone acts at the central nervous system. In conclusion, in conscious rabbits, 1) intracerebroventricular μ- and θs-receptor agonists caused pressor responses and 2) μ-opioid agonist altered baroreceptor reflex control of renal sympathetic nerve activity and produced changes in sympathoadrenal responses.

Original languageEnglish
Pages (from-to)648-652
Number of pages5
Issue number6
Publication statusPublished - Jun 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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