Differential expression of insulin-like growth factor 1 in human primary liver cancer.

Yasuharu Ikeda; Kiyoshi Kajiyama; Yo Ichi Yamashita; Toru Ikegami; Hideaki Uchiyama; Yuji Soejima; Hirofumi Kawanaka; Tetsuo Ikeda; Masaru Morita; Eiji Oki; Hiroshi Saeki; Taketoshi Suehiro; Kohshi Mimori; Keishi Sugimachi; Ken Shirabe; Yoshihiko Maehara

Differential expression of insulin-like growth factor 1 in human primary liver cancer.

Yasuharu Ikeda, Kiyoshi Kajiyama, Yo Ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Masaru Morita, Eiji Oki, Hiroshi Saeki, Taketoshi Suehiro, Kohshi Mimori, Keishi Sugimachi, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

Original language	English
Pages (from-to)	334-338
Number of pages	5
Journal	Unknown Journal
Volume	104
Issue number	10
Publication status	Published - Oct 2013

All Science Journal Classification (ASJC) codes

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{1fae1d0b260e4a778b66324ddbeb4583,

title = "Differential expression of insulin-like growth factor 1 in human primary liver cancer.",

abstract = "Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.",

author = "Yasuharu Ikeda and Kiyoshi Kajiyama and Yamashita, {Yo Ichi} and Toru Ikegami and Hideaki Uchiyama and Yuji Soejima and Hirofumi Kawanaka and Tetsuo Ikeda and Masaru Morita and Eiji Oki and Hiroshi Saeki and Taketoshi Suehiro and Kohshi Mimori and Keishi Sugimachi and Ken Shirabe and Yoshihiko Maehara",

year = "2013",

month = oct,

language = "English",

volume = "104",

pages = "334--338",

journal = "Unknown Journal",

issn = "1040-6182",

publisher = "Elsevier Limited",

number = "10",

}

TY - JOUR

T1 - Differential expression of insulin-like growth factor 1 in human primary liver cancer.

AU - Ikeda, Yasuharu

AU - Kajiyama, Kiyoshi

AU - Yamashita, Yo Ichi

AU - Ikegami, Toru

AU - Uchiyama, Hideaki

AU - Soejima, Yuji

AU - Kawanaka, Hirofumi

AU - Ikeda, Tetsuo

AU - Morita, Masaru

AU - Oki, Eiji

AU - Saeki, Hiroshi

AU - Suehiro, Taketoshi

AU - Mimori, Kohshi

AU - Sugimachi, Keishi

AU - Shirabe, Ken

AU - Maehara, Yoshihiko

PY - 2013/10

Y1 - 2013/10

N2 - Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

AB - Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=84897576868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897576868&partnerID=8YFLogxK

M3 - Article

C2 - 24511663

AN - SCOPUS:84897576868

SN - 1040-6182

VL - 104

SP - 334

EP - 338

JO - Unknown Journal

JF - Unknown Journal

IS - 10

ER -

Differential expression of insulin-like growth factor 1 in human primary liver cancer.

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Other files and links

Fingerprint

Cite this