Differential expression of insulin-like growth factor 1 in human primary liver cancer.

Yasuharu Ikeda, Kiyoshi Kajiyama, Yo Ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Masaru Morita, Eiji Oki, Hiroshi Saeki, Taketoshi Suehiro, Kohshi Mimori, Keishi Sugimachi, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalUnknown Journal
Issue number10
Publication statusPublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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