TY - JOUR
T1 - Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic l-DOPA treatment in a rat model of Parkinson's disease
AU - Ebihara, Kosuke
AU - Ishida, Yasushi
AU - Takeda, Ryuichiro
AU - Abe, Hiroshi
AU - Matsuo, Hisae
AU - Kawai, Keiichi
AU - Magata, Yasuhiro
AU - Nishimori, Toshikazu
PY - 2011/6/1
Y1 - 2011/6/1
N2 - A study was carried out to examine the effects of acute and chronic l-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. During a course of chronic l-DOPA treatment (15. mg/day, 15 days), rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute l-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate (Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion and significantly fewer c-Fos-immunopositive cells in the Cg, the nucleus accumbens shell, and the basolateral nucleus of amygdala ipsilateral to the lesion. No significant difference was observed in the number of Zif268-immunopositive cells between the acute and chronic l-DOPA groups. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic l-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.
AB - A study was carried out to examine the effects of acute and chronic l-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. During a course of chronic l-DOPA treatment (15. mg/day, 15 days), rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute l-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate (Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion and significantly fewer c-Fos-immunopositive cells in the Cg, the nucleus accumbens shell, and the basolateral nucleus of amygdala ipsilateral to the lesion. No significant difference was observed in the number of Zif268-immunopositive cells between the acute and chronic l-DOPA groups. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic l-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.
UR - http://www.scopus.com/inward/record.url?scp=79955729001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955729001&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2011.03.087
DO - 10.1016/j.neulet.2011.03.087
M3 - Article
C2 - 21507338
AN - SCOPUS:79955729001
SN - 0304-3940
VL - 496
SP - 90
EP - 94
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -