Differential effects of five types of antipathogenic plant peptides on model membranes

José Manuel M. Caaveiro, Antonio Molina, Juan M. González-Mañas, Pablo Rodríguez-Palenzuela, Francisco García-Olmedo, Félix M. Goñi

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


The effects of five antipathogenic plant peptides, wheat α-thionin, potato PTH1 defensin, barley LTP2 lipid transfer protein, and potato tuber DL1 and DL2 defensins, have been tested against phospholipid vesicles (liposomes). Wheat thionin very actively induces aggregation and leakage of negatively charged vesicles. LTP2 displays the same activities, although to a limited extent. Under certain conditions PTH1 and DL2 induce vesicle aggregation, but not leakage. Potato defensin DL1 failed to show any effect on liposomes. The same peptides have been assayed against a plant pathogenic bacterium, both the membrane-active and -inactive compounds having efficient antibacterial action.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalFEBS Letters
Issue number2-3
Publication statusPublished - Jun 30 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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