Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography

Koji Yamashita, Hiroshi Sugimori, Akira Nakamizo, Toshiyuki Amano, Takahiro Kuwashiro, Takeharu Watanabe, Keisuke Kawamata, Kiyomi Furuya, Shino Harada, Ryotaro Kamei, Junki Maehara, Yasushi Okada, Tomoyuki Noguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Moyamoya disease (MMD) and non-MMD have different pathogenesis, clinical presentation, and treatment policy. Purpose: To identify differences in hemodynamics between MMD and non-MMD using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT). Material and Methods: Patients who had undergone 99mTc-ECD or 123I-IMP SPECT, and IVIM imaging were retrospectively studied. IVIM imaging was acquired using six different b-values. Cerebral blood flow ratio (CBFR) in the basal ganglia was calculated using a standardized volume-of-interest template. The cerebellum was used as a reference region. IVIM perfusion fraction (f) was obtained using a two-step fitting algorithm. Elliptical regions of interest were placed in bilateral basal ganglia on the IVIM f map. Patients were classified into MMD and non-MMD groups. The correlation between CBFR and mean IVIM f (fmean) in the basal ganglia was evaluated using Spearman's rank correlation coefficient. Results: In total, 20 patients with MMD and 28 non-MMD patients were analyzed. No significant differences in fmean were observed among MMD, affected hemisphere with non-MMD (non-MMDaff), and unaffected hemispheres with non-MMD (non-MMDunaff). A negative correlation was seen between fmean and CBFR in the MMD group (r = –0.40, P = 0.0108), but not in the non-MMD group (non-MMDaff, r = 0.07, P = 0.69; non-MMDunaff, r = –0.22, P = 0.29). No significant differences were found among MMD and non-MMD patients, irrespective of SPECT tracers. Conclusion: The combination of IVIM MRI and SPECT appears to allow non-invasive identification of differences in hemodynamics between MMD and non-MMD.

Original languageEnglish
Pages (from-to)769-775
Number of pages7
JournalActa Radiologica
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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