TY - JOUR
T1 - Differences in thymus dependency among the alloreactive T-cell subpopulations in their development
AU - Kawauchi, Hideyuki
AU - Shimamoto, Yoshinori
AU - Taniguchi, Kazuto
AU - Kubo, Chiharu
AU - Nomoto, Kikuo
N1 - Funding Information:
This work was supportedb y a Grant-in-Aid for Scientific Researchf rom the Ministry of Education, Sciencea nd Culture, Japan and a Grant-in-Aid for Cancer Researchf rom the Ministry of Health and Welfare, Japan.
PY - 1982/6
Y1 - 1982/6
N2 - Effects of thymectomy at various times after birth (Tx-1, Tx-3, Tx-7, Tx-14) on mixed lymphocyte reaction (MLR), cell-mediated cytotoxicity (CMC), and graft-versus-host reaction (GVHR) were examined by experiments with spleen cells obtained at 8 weeks of age. All of MLR, CMC, and GVHR were detected in spleen cells of Tx-14 mice. However, the ability of spleen cells to induce GVHR was abolished by thymectomy at 7 days after birth. On the other hand, MLR and CMC were not affected in such mice. In Tx-1 or Tx-3 mice, only MLR was detected in spleen cells. These results suggest that thymus dependency of T cells responsible for MLR are lower in their maturation than those for CMC and that thymus dependency of T cells responsible for GVHR are the highest among these T-cell subpopulations.
AB - Effects of thymectomy at various times after birth (Tx-1, Tx-3, Tx-7, Tx-14) on mixed lymphocyte reaction (MLR), cell-mediated cytotoxicity (CMC), and graft-versus-host reaction (GVHR) were examined by experiments with spleen cells obtained at 8 weeks of age. All of MLR, CMC, and GVHR were detected in spleen cells of Tx-14 mice. However, the ability of spleen cells to induce GVHR was abolished by thymectomy at 7 days after birth. On the other hand, MLR and CMC were not affected in such mice. In Tx-1 or Tx-3 mice, only MLR was detected in spleen cells. These results suggest that thymus dependency of T cells responsible for MLR are lower in their maturation than those for CMC and that thymus dependency of T cells responsible for GVHR are the highest among these T-cell subpopulations.
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U2 - 10.1016/0008-8749(82)90134-4
DO - 10.1016/0008-8749(82)90134-4
M3 - Article
C2 - 6214317
AN - SCOPUS:0019994113
SN - 0008-8749
VL - 70
SP - 76
EP - 84
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -