TY - JOUR
T1 - Difference in thymus dependency between effector and suppressor T cells for delayed footpad reaction to sheep erythrocytes in mice
AU - Shimamoto, Yoshinori
AU - Kubo, Chiharu
AU - Taniguchi, Kazuto
AU - Nomoto, Kikuo
N1 - Funding Information:
This work was supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, and a grant-in-aid for Cancer Research from the Ministry of Health and Welfare, Japan.
PY - 1981/6
Y1 - 1981/6
N2 - Effects of thymectomy at various times after birth on effector and suppressor T cells for a delayed footpad reaction were determined in 6-week-old mice immunized intraperitoneally (ip) with sheep erythrocytes (SRBC). Mice thymectomized 1 day after birth (Tx-1 mice) gave delayed footpad reactions weaker than those of mice thymectomized 7 days after birth (Tx-7 mice) or sham operated (SH mice) after immunization with a low dose of SRBC. After immunization with a high dose of SRBC, on the other hand, Tx-1 mice showed reactions stronger than those of Tx-7 or SH mice. Pretreatment with cyclophosphamide (CY) augmented the delayed footpad reaction in Tx-7 or SH mice, but not in Tx-1 mice, immunized with a high dose of SRBC. The presence of T cells suppressive for the delayed footpad reaction in the spleen of Tx-7 or SH mice was confirmed by cell transfer experiments. These results suggest that effector T cells responsible for a delayed footpad reaction to SRBC are less thymus dependent and require the presence of the thymus for a shorter period in their development compared to suppressor T cells.
AB - Effects of thymectomy at various times after birth on effector and suppressor T cells for a delayed footpad reaction were determined in 6-week-old mice immunized intraperitoneally (ip) with sheep erythrocytes (SRBC). Mice thymectomized 1 day after birth (Tx-1 mice) gave delayed footpad reactions weaker than those of mice thymectomized 7 days after birth (Tx-7 mice) or sham operated (SH mice) after immunization with a low dose of SRBC. After immunization with a high dose of SRBC, on the other hand, Tx-1 mice showed reactions stronger than those of Tx-7 or SH mice. Pretreatment with cyclophosphamide (CY) augmented the delayed footpad reaction in Tx-7 or SH mice, but not in Tx-1 mice, immunized with a high dose of SRBC. The presence of T cells suppressive for the delayed footpad reaction in the spleen of Tx-7 or SH mice was confirmed by cell transfer experiments. These results suggest that effector T cells responsible for a delayed footpad reaction to SRBC are less thymus dependent and require the presence of the thymus for a shorter period in their development compared to suppressor T cells.
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U2 - 10.1016/0008-8749(81)90365-8
DO - 10.1016/0008-8749(81)90365-8
M3 - Article
C2 - 6455200
AN - SCOPUS:0019453532
SN - 0008-8749
VL - 61
SP - 190
EP - 199
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -