Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice

Shoichiro Tsuyama, Daichi Oikawa, Yukiko Tsuji, Yoriko Akimoto, Hiroyuki Jikuya, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Conjugated linoleic acid (CLA) has a role of biogenic regulation through modifying prostaglandin production. However, its effects on related metabolites of arachidonate remain unclear. Therefore, the effects of CLA on brain endocannabinoid content as well as its analogs were investigated.Mice (3-week-old), provided with diets containing 3% linoleic acid or 3% CLA for 4 weeks, were sacrificed and lipids were extracted from their cerebral cortex and hypothalamus. The amounts of N-arachidonoyl-ethanolamide, 2-arachidonoyl- glycerol (2-AG), oleoyl-ethanolamide and palmitoylethanolamide were determined quantitatively by LC-MS. The 2-AG level in the cerebral cortex was significantly decreased by CLA treatment, but the other compounds were unaffected in the cerebral cortex and hypothalamus. The present study indicated that dietary CLA site-selectively decreases 2-AG in the cerebral cortex.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalNutritional Neuroscience
Issue number4
Publication statusPublished - Aug 1 2009

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • General Neuroscience
  • Nutrition and Dietetics


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