Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice

Satomi Yano, Daisuke Umeda, Norihide Maeda, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Flavonoids ubiquitously exist in plants, vegetables, fruits, and teas. We evaluated the effect of dietary apigenin, one of the well-known flavonoids, on the immune system in C57BL/6N mice. Mice were fed experimental diets containing apigenin for 2 weeks. After the experimental period, there was no significant difference in body and organ weights between the control and the apigenin group. The total immunoglobulin (Ig) E levels in mice fed apigenin were significantly suppressed, whereas levels of IgG, IgM, and IgA were not affected. We also examined the effect of the apigenin diet on cytokine expression in mice sera using a cytokine array. The production of regulated upon activation normal T cell expressed and secreted (RANTES) and soluble tumor necrosis factor receptor I (sTNFRI) in mice sera was down-regulated by the apigenin diet. These results suggest that a diet containing apigenin can reduce serum IgE and inflammatory cytokines such as RANTES and sTNFRI in mice.

Original languageEnglish
Pages (from-to)5203-5207
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Issue number14
Publication statusPublished - Jul 12 2006

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Agricultural and Biological Sciences


Dive into the research topics of 'Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice'. Together they form a unique fingerprint.

Cite this